CXCR4 antagonist AMD3100 ameliorates thyroid damage in autoimmune thyroiditis in NOD.H-2h4 mice

CXCR4 Antagonist AMD3100 Accelerates Impaired Wound Healing in Diabetic Mice

The antagonism of CXC-chemokine receptor 4 (CXCR4) with AMD3100 improves cardiac performance after myocardial infarction by augmenting the recruitment of endothelial progenitor cells (EPCs) from the bone marrow to the regenerating vasculature. We investigated whether AMD3100 may accelerate diabetes-impaired wound healing through a similar mechanism. Skin wounds were made on the backs of leptin ...

Early requirement for B cells for development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice.

B cells are known to play an important role in the pathogenesis of several autoimmune diseases. NOD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) and anti-mouse thyroglobulin (MTg) autoantibodies, the levels of which correlate closely with the severity of thyroid lesions. NOD.H-2h4 mice genetically deficient in B cells (NOD.Kmu(null)) or rendered B cell-deficient by treatment from...

B cell depletion inhibits spontaneous autoimmune thyroiditis in NOD.H-2h4 mice.

B cells are important for the development of most autoimmune diseases. B cell depletion immunotherapy has emerged as an effective treatment for several human autoimmune diseases, although it is unclear whether B cells are necessary for disease induction, autoantibody production, or disease progression. To address the role of B cells in a murine model of spontaneous autoimmune thyroiditis (SAT),...

Thyroid Disease and Autoimmune Thyroiditis

Hypothyroidism is the most common endocrine disorder of canines, and up to 80% of cases result from autoimmune (lymphocytic) thyroiditis. The heritable nature of this disorder poses significant genetic implications for breeding stock. Thus, accurate diagnosis of the early compensatory stages of canine autoimmune thyroiditis leading up to hypothyroidism affords important genetic and clinical opt...

Dual Roles for IFN- , But Not for IL-4, in Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice